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a change of circumstances or fortune, typically one that is unwelcome or unpleasant.vicissitude(noun)
a variation in circumstances or fortune at different times in your life or in the development of something
"the project was subject to the usual vicissitudes of exploratory research"vicissitude(noun)
mutability in life or nature (especially successive alternation from one condition to another)a negative event or circumstance that is common to a particular setting or situation and is usually beyond one's control
The vicissitudes of medical school proved too much for the anxious student.